Quality of Life of Chronic Liver Disease Patients: A Narrative Review

Abstract

Background: Chronic liver disease (CLD), encompassing conditions such as cirrhosis, hepatitis, and nonalcoholic
fatty liver disease, significantly compromises patients’ physical, emotional, andsocialwell-being.
Whileclinicalmanagementoftenemphasizesphysiological outcomes, the broader impact on health-related quality
of life (HRQOL) is frequently overlooked.
Objective: This narrative review aims to synthesise existing literature on the multidimensional effects of CLD on
patients’ quality of life, highlighting key determinants and advocating for a holistic, patient-centred approach
to care.
Methods: Astructured literature search was conducted using databases such as PubMed, Scopus, and Google
Scholar. Sixteen peer-reviewed studies meeting predefined inclusion criteria were analysed thematically across
three domains: physical health, psychological well-being, and social functioning. Validat quality of life tools,
especially the SF-36 Health Survey, were central to evaluation.
Results: The findings reveal that fatigue, mobility limitations, and chronic pain are prevalent physical symptoms
that impair daily functioning. Psychologically, CLD patients experience high rates of depression, anxiety, and
cognitive decline, further reducing treatment adherence and emotional resilience. Socially, stigma, financial
burden, and weakened support systems contribute to isolation and diminished well-being.
Conclusion: CLD imposes a profound burden on quality of life across physical, emotional, andsocialdomains.
Addressingtheseinterconnectedchallengesrequiresmorethanclinical intervention—it necessitates integrated
care strategies involving psychological support, rehabilitation, and community-based resources. A shift toward
holistic care is essential for improving the lived experiences of individuals with chronic liver disease.